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Article

p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis.

Cell death & disease - 23 Jul 2020

Ye Shengfan, Zhao Ting, Zhang Wei, Tang Zimu, Gao Ce, Ma Zhipeng, Xiong Jing-Wei, Peng Jinrong, Tan Wei-Qiang, Chen Jun

Abstract excerpt

Neonatal mice and adult zebrafish can fully regenerate their hearts through proliferation of pre-existing cardiomyocytes. Previous studies have revealed that p53 signalling is activated during cardiac regeneration in neonatal mice and that hydrogen peroxide (H2O2) generated near the wound site acts as a novel signal to promote zebrafish heart regeneration. We recently demonstrated that the expression of the p53...

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Identifiers

PMID: 32703938
DOI: 10.1038/s41419-020-02781-7
PMCID: PMC7378207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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