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Article

H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration

3 Sept 2019

Abstract excerpt

ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal, such as zebrafish, represents an attractive inroad towards regenerating the human heart. Using integrated high-throughput transcriptional and chromatin analyses, we have identified a strong association between H3K27me3 deposition and reduced sarcomere and cytoskeletal...

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PMID: 31427288
DOI: 10.1242/dev.178632

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