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Article

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis.

Journal of molecular and cellular cardiology - 1 Mar 2015

Xie Liang, Pi Xinchun, Wang Zhongjing, He Jun, Willis Monte S, Patterson Cam

Abstract excerpt

PHD3, a member of a family of Prolyl-4 Hydroxylase Domain (PHD) proteins, has long been considered a pro-apoptotic protein. Although the pro-apoptotic effect of PHD3 requires its prolyl hydroxylase activity, it may be independent of HIF-1α, the common substrate of PHDs. PHD3 is highly expressed in the heart, however, its role in cardiomyocyte apoptosis remains unclear. This study was undertaken to determine...

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Identifiers

PMID: 25633836
DOI: 10.1016/j.yjmcc.2015.01.007
PMCID: PMC4374643

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