Article
Ultradeep sequencing reveals HIV-1 diversity and resistance compartmentalization during HIV-encephalopathy.
AIDS (London, England) - 1 Sept 2020
Giatsou Eleni, Abdi Basma, Plu Isabelle, Desire Nathalie, Palich Romain, Calvez Vincent, Seilhean Danielle, Marcelin Anne-Geneviève, Jary Aude
Abstract excerpt
OBJECTIVES: To examine viral diversity and resistance mutations in different brain areas in cases of HIV-encephalopathy. DESIGN: Twelve postmortem brain areas from three cases of possible or certain HIV-encephalopathy were analyzed. METHODS: After amplification of the reverse transcriptase and the V3 loop region of the gp120 protein, ultradeep sequencing was performed with Illumina technology. Phylogenetic...
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