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Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization properties

25 Aug 2017

Abstract excerpt

Compartmentalization of HIV-1 has been observed in the cerebrospinal fluid (CSF) of patients at different clinical stages. Considering the low permeability of the blood-brain barrier, we wondered if a reduced selective pressure by neutralizing antibodies (NAb) in the central nervous system (CNS) could favor the evolution of NAb-sensitive viruses in this compartment. Single genome amplification (SGA) was used to...

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PMID: 28841647
DOI: 10.1371/journal.pone.0181680

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