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Article

Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis.

Thoracic cancer - 1 Sept 2020

Yoo Seung Soo, Lee Jang Hyuck, Hong Mi Jeong, Choi Jin Eun, Kang Hyo-Gyoung, Do Sook Kyung, Kim Ji Hyun, Baek Sun Ah, Choi Sun Ha, Lee Won Kee, Lee Yong Hoon, Seo Hyewon, Lee Jaehee, Lee Shin Yup, Cha Seung Ick, Kim Chang Ho, Park Jae Yong

Abstract excerpt

Deltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC). DTX1 rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32700476
DOI: 10.1111/1759-7714.13566
PMCID: PMC7471053

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