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Polymorphisms of the PD-L1 gene 3'-untranslated region are associated with the expression of PD-L1 in non-small cell lung cancer.

Genes, chromosomes & cancer - 1 Jan 2024

Ohhara Yoshihito, Tomaru Utano, Kinoshita Ichiro, Hatanaka Kanako C, Noguchi Takuro, Hatanaka Yutaka, Amono Toraji, Matsuno Yoshihiro, Dosaka-Akita Hirotoshi

Abstract excerpt

Recent results show that polymorphisms of programmed death ligand 1 (PD-L1, also known as CD274 or B7-H1) might be used as a possible marker for effectiveness of chemotherapy and cancer risk. However, the effect of PD-L1 gene variations on PD-L1 expression remain unclear. Given the post-transcriptional machinery in tumor PD-L1 expression, we investigated single nucleotide polymorphisms (SNPs) in the...

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PMID: 38169142
DOI: 10.1002/gcc.23216

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