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Article

Genetic variants of NEUROD1 target genes are associated with clinical outcomes of small-cell lung cancer patients.

Thoracic cancer - 1 May 2023

Lee Sunwoong, Yoo Seung Soo, Choi Jin Eun, Hong Mi Jeong, Do Sook Kyung, Lee Jang Hyuck, Lee Won Ki, Park Ji Eun, Choi Sun Ha, Seo Hyewon, Lee Jaehee, Lee Shin Yup, Cha Seung Ick, Kim Chang Ho, Kang Hyo-Gyoung, Park Jae Yong

Abstract excerpt

BACKGROUND: Neurogenic differentiation factor 1 (NEUROD1) is frequently overexpressed in small-cell lung cancer (SCLC). NEUROD1 plays an important role in promoting malignant behavior and survival. METHODS: In this study, we evaluated the association between putative functional polymorphisms in 45 NEUROD1 target genes and chemotherapy response and survival outcomes in 261 patients with SCLC. Among the 100 single...

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Identifiers

PMID: 36935366
DOI: 10.1111/1759-7714.14839
PMCID: PMC10151137

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