Article
Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
Nature communications - 1 Oct 2021
Jiang Yan, Fu Xing, Zhang Yuhan, Wang Shen-Fei, Zhu Hong, Wang Wei-Kang, Zhang Lin, Wu Ping, Wong Catherine C L, Li Jinsong, Ma Jinbiao, Guan Ji-Song, Huang Ying, Hui Jingyi
Abstract excerpt
Rett syndrome (RTT) is a severe neurological disorder and a leading cause of intellectual disability in young females. RTT is mainly caused by mutations found in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). Despite extensive studies, the molecular mechanism underlying RTT pathogenesis is still poorly understood. Here, we report MeCP2 as a key subunit of a higher-order multiunit protein complex...
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