Article
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.
Cell reports - 21 Jul 2020
Lee Michael C, Nahorski Michael S, Hockley James R F, Lu Van B, Ison Gillian, Pattison Luke A, Callejo Gerard, Stouffer Kaitlin, Fletcher Emily, Brown Christopher, Drissi Ichrak, Wheeler Daniel, Ernfors Patrik, Menon David, Reimann Frank, Smith Ewan St John, Woods C Geoffrey
Abstract excerpt
By studying healthy women who do not request analgesia during their first delivery, we investigate genetic effects on labor pain. Such women have normal sensory and psychometric test results, except for significantly higher cuff pressure pain. We find an excess of heterozygotes carrying the rare allele of SNP rs140124801 in KCNG4. The rare variant KV6.4-Met419 has a dominant-negative effect and cannot modulate...
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