Article
Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
Cell reports - 7 Jul 2020
Moscato Emilia H, Dubowy Christine, Walker James A, Kayser Matthew S
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder associated with social and communicative disabilities. The cellular and circuit mechanisms by which loss of neurofibromin 1 (Nf1) results in social deficits are unknown. Here, we identify social behavioral dysregulation with Nf1 loss in Drosophila. These deficits map to primary dysfunction of a group of peripheral sensory neurons. Nf1 regulation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.