Mouse models of neurofibromatosis type I: bridging the GAP.

Abstract excerpt

Neurofibromatosis type I (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, leading to a variety of abnormalities in cell growth and differentiation, and to learning disabilities. The protein encoded by NF1, neurofibromin, has several biochemical functions and is expressed in a variety of different cell populations. Hence, determination of the molecular and cellular mechanisms that...

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