IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.

doi:10.4049/jimmunol.1700807

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Article

IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2017

Obajemu Adeola A, Rao Nina, Dilley Kari A, Vargas Joselin M, Sheikh Faruk, Donnelly Raymond P, Shabman Reed S, Meissner Eric G, Prokunina-Olsson Ludmila, Onabajo Olusegun O

Abstract excerpt

Type III IFNs are important mediators of antiviral immunity. IFN-λ4 is a unique type III IFN because it is produced only in individuals who carry a dG allele of a genetic variant rs368234815-dG/TT. Counterintuitively, those individuals who can produce IFN-λ4, an antiviral cytokine, are also less likely to clear hepatitis C virus infection. In this study, we searched for unique functional properties of IFN-λ4 that...

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PMID: 29070670
DOI: 10.4049/jimmunol.1700807
PMCID: PMC5698113

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SOCS1
USP18

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