Article
Antipsychotic Behavioral Phenotypes in the Mouse Collaborative Cross Recombinant Inbred Inter-Crosses (RIX).
G3 (Bethesda, Md.) - 2 Sept 2020
Giusti-Rodríguez Paola, Xenakis James G, Crowley James J, Nonneman Randal J, DeCristo Daniela M, Ryan Allison, Quackenbush Corey R, Miller Darla R, Shaw Ginger D, Zhabotynsky Vasyl, Sullivan Patrick F, Manuel de Villena Fernando Pardo, Zou Fei
Abstract excerpt
Schizophrenia is an idiopathic disorder that affects approximately 1% of the human population, and presents with persistent delusions, hallucinations, and disorganized behaviors. Antipsychotics are the standard pharmacological treatment for schizophrenia, but are frequently discontinued by patients due to inefficacy and/or side effects. Chronic treatment with the typical antipsychotic haloperidol causes tardive...
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