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Article

Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2012

Crowley James J, Kim Yunjung, Szatkiewicz Jin Peng, Pratt Amanda L, Quackenbush Corey R, Adkins Daniel E, van den Oord Edwin, Bogue Molly A, Yang Hyuna, Wang Wei, Threadgill David W, de Villena Fernando Pardo-Manuel, McLeod Howard L, Sullivan Patrick F

Abstract excerpt

Tardive dyskinesia (TD) is a debilitating, unpredictable, and often irreversible side effect resulting from chronic treatment with typical antipsychotic agents such as haloperidol. TD is characterized by repetitive, involuntary, purposeless movements primarily of the orofacial region. In order to investigate genetic susceptibility to TD, we used a validated mouse model for a systems genetics analysis geared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22207321
DOI: 10.1007/s00335-011-9385-8
PMCID: PMC3356790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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