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Genetic mouse models relevant to schizophrenia: taking stock and looking forward.

Neuropharmacology - 1 Mar 2012

Harrison Paul J, Pritchett David, Stumpenhorst Katharina, Betts Jill F, Nissen Wiebke, Schweimer Judith, Lane Tracy, Burnet Philip W J, Lamsa Karri P, Sharp Trevor, Bannerman David M, Tunbridge Elizabeth M

Abstract excerpt

Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of...

Topics

Animals
Disease Models, Animal
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Mice
Schizophrenia

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21864547
DOI: 10.1016/j.neuropharm.2011.08.009

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