Article
Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models.
Biological psychiatry - 15 Jun 2006
Chen Jingshan, Lipska Barbara K, Weinberger Daniel R
Abstract excerpt
Translation of human genetic mutations into genetic mouse models is an important strategy to study the pathogenesis of schizophrenia, identify potential drug targets, and test new drugs for new antipsychotic treatments. Although it is impossible to recapitulate the full spectrum of schizophrenia symptoms in animal models, hypothesis-driven genetic mouse models have been successful in reproducing several...
Topics
- Animals
- Behavior, Animal
- Disease Models, Animal
- Dopamine
- Genetic Predisposition to Disease
- Glutamine
- Mice
- Models, Genetic
- Schizophrenia