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Article

Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.

Immunogenetics - 1 Nov 2002

van Lith Marcel, van Ham Marieke, Neefjes Jacques

Abstract excerpt

In B cells, HLA-DO controls HLA-DM-mediated peptide loading on MHC class II molecules. We analyzed whether HLA-DO mutations are associated with autoimmune diseases characterized by an autoantibody component and with a linkage to HLA-DR or HLA-DQ. These diseases include systemic lupus erythematosu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12439622
DOI: 10.1007/s00251-002-0500-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12439622-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.PMID 12439622Read ↗

The HLA-DOB gene displays limited polymorphism with only one amino acid substitution.Semantic proximity Read ↗

Limited polymorphism in the HLA-DOA gene.Semantic proximity Read ↗

Human Hepatitis B Viral Infection Outcomes Are Linked to Naturally Occurring Variants of HLA-DOA That Have Altered Function.Semantic proximity Read ↗

Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*.Semantic proximity Read ↗

Identification of a novel HLA-DOB-allele, DOB*010103, by sequence-based typing in the Korean population.Semantic proximity Read ↗

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.Semantic proximity Read ↗

A novel DO null allele with a c.268C>T (p.Gln90Stop) mutation in Japanese.Semantic proximity Read ↗

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.Semantic proximity Read ↗

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.Semantic proximity Read ↗

HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Class II transactivator is required for maximal expression of HLA-DOB in B cells.Semantic proximity Read ↗

Analysis of HLA-DMB mutants and -DMB genomic structure.Semantic proximity Read ↗

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