Article
Human pharmacogenomic variation of antihypertensive drugs: from population genetics to personalized medicine.
Pharmacogenomics - 1 Feb 2014
Polimanti Renato, Iorio Andrea, Piacentini Sara, Manfellotto Dario, Fuciarelli Maria
Abstract excerpt
AIM: To investigate the human pharmacogenetic variation related to antihypertensive drugs, providing a survey of functional interpopulation differences in hypertension pharmacogenes. MATERIALS & METHODS: The study was divided into two stages. In the first stage, we analyzed 1249 variants located in 57 hypertension pharmacogenes. This first-stage analysis confirmed that geographic origin strongly affects...
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