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Article

OTX1 and OTX2 Expression Correlates With the Clinicopathologic Classification of Medulloblastomas

1 Feb 2006

Abstract excerpt

OTX1 and OTX2 are transcription factors with an essential role in the development of the cerebellum. We previously described a high OTX2 expression in medulloblastoma. Here, we analyzed amplification and mRNA expression of OTX1 and OTX2 in a series of human medulloblastomas. In addition, OTX2 protein expression was analyzed on tissue arrays. The OTX2 gene was amplified in the medulloblastoma cell line D425 and...

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PMID: 16462208
DOI: 10.1097/01.jnen.0000199576.70923.8a

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