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Article

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

30 Sept 2011

Abstract excerpt

The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. To study the role OTX2 has in medulloblastoma we investigated the downstream pathway of OTX2. We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible...

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PMID: 21964830
DOI: 10.1002/ijc.26474

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