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Article

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Diabetes - 1 Feb 2001

Frayling T M, Evans J C, Bulman M P, Pearson E, Allen L, Owen K, Bingham C, Hannemann M, Shepherd M, Ellard S, Hattersley A T

Abstract excerpt

beta-Cell transcription factor genes are important in the pathophysiology of the beta-cell, with mutations in hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, insulin promoter factor (IPF)-1, HNF-1beta, and NeuroD1/BETA2, all resulting in early-onset type 2 diabetes. We assessed the relative c...

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Identifiers

PMID: 11272211
DOI: 10.2337/diabetes.50.2007.s94

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11272211-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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