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Article

Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2020

Ni Ming, Zhou Haoming, Zhang Jing, Jin Dan, Lu Tianfei, Busuttil Ronald W, Kupiec-Weglinski Jerzy W, Wang Xuehao, Zhai Yuan

Abstract excerpt

Glycogen synthase kinase 3 (Gsk3) α and β are both constitutively active and inhibited upon stimulation by N-terminal serine phosphorylation. Although roles of active Gsk3 in liver ischemia reperfusion injury (IRI) have been well appreciated, whether Gsk3 N-terminal serine phosphorylation has any functional significance in the disease process remains unclear. In a murine liver partial warm ischemia model, we...

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Identifiers

PMID: 32680958
DOI: 10.4049/jimmunol.2000397
PMCID: PMC8788336

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