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Article

Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy.

Molecular cell - 8 Jan 2015

Wilkinson Deepti S, Jariwala Jinel S, Anderson Ericka, Mitra Koyel, Meisenhelder Jill, Chang Jessica T, Ideker Trey, Hunter Tony, Nizet Victor, Dillin Andrew, Hansen Malene

Abstract excerpt

The protein LC3 is indispensible for the cellular recycling process of autophagy and plays critical roles during cargo recruitment, autophagosome biogenesis, and completion. Here, we report that LC3 is phosphorylated at threonine 50 (Thr(50)) by the mammalian Sterile-20 kinases STK3 and STK4. Loss of phosphorylation at this site blocks autophagy by impairing fusion of autophagosomes with lysosomes, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25544559
DOI: 10.1016/j.molcel.2014.11.019
PMCID: PMC4373083

Genes

STK3
STK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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