Article
Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.
The New England journal of medicine - 2 Jun 2016
Nioi Paul, Sigurdsson Asgeir, Thorleifsson Gudmar, Helgason Hannes, Agustsdottir Arna B, Norddahl Gudmundur L, Helgadottir Anna, Magnusdottir Audur, Jonasdottir Aslaug, Gretarsdottir Solveig, Jonsdottir Ingileif, Steinthorsdottir Valgerdur, Rafnar Thorunn, Swinkels Dorine W, Galesloot Tessel E, Grarup Niels, Jørgensen Torben, Vestergaard Henrik, Hansen Torben, Lauritzen Torsten, Linneberg Allan, Friedrich Nele, Krarup Nikolaj T, Fenger Mogens, Abildgaard Ulrik, Hansen Peter R, Galløe Anders M, Braund Peter S, Nelson Christopher P, Hall Alistair S, Williams Michael J A, van Rij Andre M, Jones Gregory T, Patel Riyaz S, Levey Allan I, Hayek Salim, Shah Svati H, Reilly Muredach, Eyjolfsson Gudmundur I, Sigurdardottir Olof, Olafsson Isleifur, Kiemeney Lambertus A, Quyyumi Arshed A, Rader Daniel J, Kraus William E, Samani Nilesh J, Pedersen Oluf, Thorgeirsson Gudmundur, Masson Gisli, Holm Hilma, Gudbjartsson Daniel, Sulem Patrick, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
BACKGROUND: Several sequence variants are known to have effects on serum levels of non-high-density lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. METHODS: We sequenced the genomes of 2636 Icelanders and found variants that we then imputed into the genomes of approximately 398,000 Icelanders. We tested for association between these imputed variants and non-HDL cholesterol levels in...
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