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Article

Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.

Genes & development - 1 Aug 2020

Lin Lin, Lemieux George A, Enogieru Osatohanmwen Jessica, Giacomini Kathleen M, Ashrafi Kaveh

Abstract excerpt

Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral...

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Identifiers

PMID: 32675325
DOI: 10.1101/gad.339119.120
PMCID: PMC7397858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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