Dietary restriction promotes neuronal resilience via ADIOL

Abstract excerpt

<h4>ABSTRACT</h4> The steroid hormone 5-androstene-3β,17β-diol (ADIOL) was discovered in humans nearly a century ago, yet its physiological roles remain poorly defined. Here, we show that fasting and caloric restriction, two forms of dietary restriction, induce transcriptional upregulation of genes encoding CYP11A1, CYP17A1, and 17β-hydroxysteroid dehydrogenase family enzymes, promoting ADIOL biosynthesis. ADIOL,...

Topics

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• Autophagy
• Caenorhabditis elegans
• Caenorhabditis elegans Proteins
• Caloric Restriction
• Diet and metabolism studies
• Dietary Effects on Health
• Genetics, Aging, and Longevity in Model Organisms
• Tryptophan and brain disorders

Identifiers and source

Literature Corpus work

8c84b6b9-c790-5946-90c7-4dfceaa32ed2

DOI

10.1101/2025.06.25.661551