Article
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2023
Li Donghe, Farrell John J, Mez Jesse, Martin Eden R, Bush William S, Ruiz Agustin, Boada Mercè, de Rojas Itziar, Mayeux Richard, Haines Jonathan L, Vance Margaret A Pericak, Wang Li-San, Schellenberg Gerard D, Lunetta Kathryn L, Farrer Lindsay A
Abstract excerpt
INTRODUCTION: Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA). METHODS: We applied principal component analysis using Gaussian mixture models and an Ashkenazi Jewish (AJ) reference genome-wide association study (GWAS) data set to identify Ashkenazi Jews ascertained in GWAS (n = 42,682), whole genome sequencing (WGS, n = 16,815), and whole exome sequencing (WES,...
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