Article
Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3.
Genes and immunity - 1 Jan 2000
Zhang W, Hui K Y, Gusev A, Warner N, Ng S M E, Ferguson J, Choi M, Burberry A, Abraham C, Mayer L, Desnick R J, Cardinale C J, Hakonarson H, Waterman M, Chowers Y, Karban A, Brant S R, Silverberg M S, Gregersen P K, Katz S, Lifton R P, Zhao H, Nuñez G, Pe'er I, Peter I, Cho J H
Abstract excerpt
The Ashkenazi Jewish population has a several-fold higher prevalence of Crohn's disease (CD) compared with non-Jewish European ancestry populations and has a unique genetic history. Haplotype association is critical to CD etiology in this population, most notably at NOD2, in which three causal, uncommon and conditionally independent NOD2 variants reside on a shared background haplotype. We present an analysis of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.