Article
Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells.
Cells - 11 Jul 2020
Krokidis Marios G, D'Errico Mariarosaria, Pascucci Barbara, Parlanti Eleonora, Masi Annalisa, Ferreri Carla, Chatgilialoglu Chryssostomos
Abstract excerpt
Cockayne Syndrome (CS) is an autosomal recessive neurodegenerative premature aging disorder associated with defects in nucleotide excision repair (NER). Cells from CS patients, with mutations in CSA or CSB genes, present elevated levels of reactive oxygen species (ROS) and are defective in the repair of a variety of oxidatively generated DNA lesions. In this study, six purine lesions were ascertained in wild type...
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