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Article

Repair of oxidatively generated DNA damage in Cockayne syndrome.

Mechanisms of ageing and development - 1 Jan 2000

Khobta Andriy, Epe Bernd

Abstract excerpt

Defects in the repair of endogenously (especially oxidatively) generated DNA modifications and the resulting genetic instability can potentially explain the clinical symptoms of Cockayne syndrome (CS), a hereditary disease characterized by developmental defects and neurological degeneration. In this review, we describe the evidence for the involvement of CSA and CSB proteins, which are mutated in most of the CS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23518175
DOI: 10.1016/j.mad.2013.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Repair of oxidatively generated DNA damage in Cockayne syndrome.PMID 23518175Read ↗

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Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations.Semantic proximity Read ↗

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and agingSemantic proximity Read ↗

Cockayne Syndrome Group B (CSB): The Regulatory Framework Governing the Multifunctional Protein and Its Plausible Role in Cancer.Semantic proximity Read ↗

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8‐hydroxyguanine and 8‐hydroxyadenine resulting from oxidative stressSemantic proximity Read ↗

Unraveling DNA repair in human: molecular mechanisms and consequences of repair defect.Semantic proximity Read ↗

Disorders of nucleotide excision repair.Semantic proximity Read ↗

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.Semantic proximity Read ↗

Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells.Semantic proximity Read ↗

Transcription-coupled repair of DNA–protein crosslinksSemantic proximity Read ↗

Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product.Semantic proximity Read ↗

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