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Article

Development of Castration Resistant Prostate Cancer can be Predicted by a DNA Hypermethylation Profile

7 Nov 2015

Abstract excerpt

PURPOSE: Detection of DNA hypermethylation has emerged as a novel molecular biomarker for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a hypermethylation profile of patients with prostate cancer on androgen deprivation would predict castrate resistant prostate cancer. MATERIALS AND METHODS: Genome-wide methylation analysis was performed using a methylation cancer panel in 10...

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PMID: 26551297
DOI: 10.1016/j.juro.2015.10.172

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