Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer.

doi:10.1158/1078-0432.CCR-16-0549

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Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017

Zhao Shanshan, Geybels Milan S, Leonardson Amy, Rubicz Rohina, Kolb Suzanne, Yan Qingxiang, Klotzle Brandy, Bibikova Marina, Hurtado-Coll Antonio, Troyer Dean, Lance Raymond, Lin Daniel W, Wright Jonathan L, Ostrander Elaine A, Fan Jian-Bing, Feng Ziding, Stanford Janet L

Abstract excerpt

PURPOSE: Aside from Gleason sum, few factors accurately identify the subset of prostate cancer patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. EXPERIMENTAL DESIGN: Epigenome-wide DNA methylation profiling was performed in surgically resected primary tumor tissues from a population-based (n = 430) and a...

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PMID: 27358489
DOI: 10.1158/1078-0432.CCR-16-0549
PMCID: PMC5199634

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ALKBH5
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