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TET3 overexpression facilitates DNA reprogramming and early development of bovine SCNT embryos

16 Jun 2020

Abstract excerpt

Somatic cell nuclear transfer (SCNT) has been successfully used for cloning in a variety of mammalian species. However, SCNT reprogramming efficiency is relatively low, in part, due to incomplete DNA methylation reprogramming of donor cell nuclei. We previously showed that ten-eleven translocation 3 (TET3) is responsible for active DNA demethylation during preimplantation embryonic development in bovines. In this...

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PMID: 32544877
DOI: 10.1530/rep-20-0021

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