Article
Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients.
Gastroenterology - 1 May 2021
Brand Eelco C, Klaassen Marjolein A Y, Gacesa Ranko, Vich Vila Arnau, Ghosh Hiren, de Zoete Marcel R, Boomsma Dorret I, Hoentjen Frank, Horjus Talabur Horje Carmen S, van de Meeberg Paul C, Willemsen Gonneke, Fu Jingyuan, Wijmenga Cisca, van Wijk Femke, Zhernakova Alexandra, Oldenburg Bas, Weersma Rinse K
Abstract excerpt
BACKGROUND & AIMS: It is currently unclear whether reported changes in the gut microbiome are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the gut microbiome of IBD-discordant and -concordant twin pairs, which offers the unique opportunity to assess individuals at increased risk of developing IBD, namely healthy cotwins from IBD-discordant twin pairs. METHODS: Fecal samples were...
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