Article
Ethnic-Specific and UV-Independent Mutational Signatures of Basal Cell Carcinoma in Koreans.
International journal of molecular sciences - 19 Jul 2025
Kim Ye-Ah, Myung Seokho, Choi Yueun, Kim Junghyun, Lee Yoonsung, Lee Kiwon, Lew Bark-Lynn, Kim Man S, Kwon Soon-Hyo
Abstract excerpt
Basal cell carcinoma (BCC), the most common skin cancer, is primarily driven by Hedgehog (Hh) and TP53 pathway alterations. Although additional pathways were implicated, the mutational landscape in Asian populations, particularly Koreans, remains underexplored. We performed whole-exome sequencing of BCC tumor tissues from Korean patients and analyzed mutations in 11 established BCC driver genes (PTCH1, SMO, GLI1,...
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