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Article

Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.

Journal of molecular medicine (Berlin, Germany) - 1 Sept 2020

Vidal-Castiñeira Jose Ramón, López-Vázquez Antonio, Diaz-Bulnes Paula, Díaz-Coto Susana, Márquez-Kisinousky Leonardo, Martínez-Borra Jesús, Navascues Carmen A, Sanz-Cameno Paloma, de la Vega Juan, Astudillo Aurora, Rodríguez Manuel, López-Larrea Carlos

Abstract excerpt

The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses, trimming peptides and loading onto HLA class I molecules. Coding single nucleotide polymorphisms within ERAP1 are associated with autoimmune diseases, viral infections, and cancer development. Our purpose was to analyze the influence of ERAP1 variants on fibrogenesis in hepatitis C virus (HCV)-infected patients. A range...

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PMID: 32647953
DOI: 10.1007/s00109-020-01948-1

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