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Article

Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b 214-222 by combinatorial peptide library screening.

Molecular immunology - 1 Sept 2020

Bovay Amandine, Zoete Vincent, Rizkallah Pierre J, Beck Konrad, Delbreil Philippe, Speiser Daniel E, Cole David K, Fuertes Marraco Silvia A

Abstract excerpt

The CD8 T cell response to the HLA-A2-restricted epitope LLWNGPMAV (LLW) of the non-structural protein 4b of Yellow Fever Virus (YFV) is remarkably immunodominant, highly prevalent and powerful in YFV-vaccinated humans. Here we used a combinatorial peptide library screening in the context of an A2/LLW-specific CD8 T cell clone to identify a superagonist that features a methionine to isoleucine substitution at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32645549
DOI: 10.1016/j.molimm.2020.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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