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NOTCH4 regulates colorectal cancer proliferation, invasiveness, and determines clinical outcome of patients

25 Apr 2018

Abstract excerpt

Notch signal has complex roles in human malignancies, which might be attributed to the diversity of Notch receptors. Here, we set out to identify the association of NOTCH4 with colorectal cancer (CRC). In the hospital-based study cohort, we investigated NOTCH4 mRNA levels in primary CRC, as well as its association with clinicopathologic characteristics. Besides, NOTCH4 cDNA and siRNA was transfected into...

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PMID: 29693251
DOI: 10.1002/jcp.26619

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