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Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy

1 Jun 2017

Abstract excerpt

Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is a complicated and often fatal cancer, and is related to a high disease-related mortality. Around 90% of mortalities are caused by the metastasis of CRC. Current treatment statistics shows a less than 5% 5-year survival for patients with metastatic disease. The development and metastasis of CRC involve multiple factors and...

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PMID: 28721076
DOI: 10.2147/ott.s139639

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