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Article

Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study.

Journal of medical genetics - 1 Aug 2018

Yang Xin, Leslie Goska, Gentry-Maharaj Aleksandra, Ryan Andy, Intermaggio Maria, Lee Andrew, Kalsi Jatinderpal K, Tyrer Jonathan, Gaba Faiza, Manchanda Ranjit, Pharoah Paul D P, Gayther Simon A, Ramus Susan J, Jacobs Ian, Menon Usha, Antoniou Antonis C

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified >30 common SNPs associated with epithelial ovarian cancer (EOC). We evaluated the combined effects of EOC susceptibility SNPs on predicting EOC risk in an independent prospective cohort study. METHODS: We genotyped ovarian cancer susceptibility single nucleotide polymorphisms (SNPs) in a nested case-control study (750 cases and 1428 controls) from the UK...

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Identifiers

PMID: 29730597
DOI: 10.1136/jmedgenet-2018-105313
PMCID: PMC6073911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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