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Article

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.

Nature - 30 Oct 1997

Skinner P J, Koshy B T, Cummings C J, Klement I A, Helin K, Servadio A, Zoghbi H Y, Orr H T

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is one of several neurodegenerative disorders caused by an expansion of a polyglutamine tract. It is characterized by ataxia, progressive motor deterioration, and loss of cerebellar Purkinje cells. To understand the pathogenesis of SCA1, we examined the subcellular localization of wild-type human ataxin-1 (the protein encoded by the SCA1 gene) and mutant ataxin-1 in the...

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Identifiers

PMID: 9353120
DOI: 10.1038/40153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.PMID 9353120Read ↗

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Ataxin-2 Binds Alpha-Actinin-1Semantic proximity Read ↗

Identification of genes that modify ataxin-1-induced neurodegeneration.Semantic proximity Read ↗

ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulationSemantic proximity Read ↗

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1Semantic proximity Read ↗

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