Article
Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand.
Heart rhythm - 1 Dec 2020
Makarawate Pattarapong, Glinge Charlotte, Khongphatthanayothin Apichai, Walsh Roddy, Mauleekoonphairoj John, Amnueypol Montawatt, Prechawat Somchai, Wongcharoen Wanwarang, Krittayaphong Rungroj, Anannab Alisara, Lichtner Peter, Meitinger Thomas, Tjong Fleur V Y, Lieve Krystien V V, Amin Ahmad S, Sahasatas Dujdao, Ngarmukos Tachapong, Wichadakul Duangdao, Payungporn Sunchai, Sutjaporn Boosamas, Wandee Pharawee, Poovorawan Yong, Tfelt-Hansen Jacob, Tanck Michael W T, Tadros Rafik, Wilde Arthur A M, Bezzina Connie R, Veerakul Gumpanart, Nademanee Koonlawee
Abstract excerpt
BACKGROUND: Mutations in SCN5A are rarely found in Thai patients with Brugada syndrome (BrS). Recent evidence suggested that common genetic variations may underlie BrS in a complex inheritance model. OBJECTIVE: The purpose of this study was to find common and rare/low-frequency genetic variants predisposing to BrS in persons in Thailand. METHODS: We conducted a genome-wide association study (GWAS) to explore the...
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