Article

A rare non-coding enhancer variant in<i>SCN5A</i>contributes to the high prevalence of Brugada syndrome in Thailand

2023-12-20

Abstract excerpt

Brugada syndrome (BrS) is a cardiac arrhythmia disorder that causes sudden death in young adults. Rare genetic variants in the SCN5A gene, encoding the Na v 1.5 sodium channel, and common non-coding variants at this locus, are robustly associated with the condition. BrS is particularly prevalent in Southeast Asia but the underlying ancestry-specific factors remain largely unknown. Here, we performed genome sequenc...

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Literature Corpus work: a8c8bbaf-7090-5aa1-887a-873522dcaa65
DOI: 10.1101/2023.12.19.23299785

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