Article
Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.
Investigative ophthalmology & visual science - 1 Jul 2020
Margeta Milica A, Letcher Sophia M, Igo Robert P, Cooke Bailey Jessica N, Pasquale Louis R, Haines Jonathan L, Butovsky Oleg, Wiggs Janey L
Abstract excerpt
Purpose: Prior studies have demonstrated that microglial activation is involved in the pathogenesis of primary open-angle glaucoma (POAG). Here we sought to identify genetic associations between POAG and variants in APOE and TREM2, genes associated with Alzheimer disease (AD) that critically regulate microglial neurodegeneration-associated molecular signature. Methods: APOE genotypes were called using imputed...
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