Article

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

2023-01-28

Abstract excerpt

LEDGF/p75 (LEDGF) main cellular cofactor of HIV-1 integrase (IN), acts as tethering factor to target integration of HIV in actively transcribed genes. Recently a class of IN inhibitors based on inhibition of LEDGF-IN interaction has been developed. We describe here a new series of IN-LEDGF allosteric inhibitors (INLAIs), with potent anti-HIV-1 activity in the one-digit nanomolar range. These compounds inhibited IN...

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Literature Corpus work: 4c5f84f5-cefd-5426-b91a-00e5ae2a0f5d
DOI: 10.1101/2023.01.28.523533

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