Article
Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
PloS one - 1 Jan 2013
Balakrishnan Mini, Yant Stephen R, Tsai Luong, O'Sullivan Christopher, Bam Rujuta A, Tsai Angela, Niedziela-Majka Anita, Stray Kirsten M, Sakowicz Roman, Cihlar Tomas
Abstract excerpt
HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs bind at the IN dimer interface and are thought to interfere primarily with viral DNA (vDNA) integration in the target cell by blocking IN-vDNA assembly as well as the IN-LEDGF/p75 interaction. Herein we show that treatment...
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