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Article

Peripheral tolerance can be modified by altering KLF2-regulated Treg migration

26 Jul 2016

Abstract excerpt

Tregs are essential for maintaining peripheral tolerance, and thus targeting these cells may aid in the treatment of autoimmunity and cancer by enhancing or reducing suppressive functions, respectively. Before these cells can be harnessed for therapeutic purposes, it is necessary to understand how they maintain tolerance under physiologically relevant conditions. We now report that transcription factor...

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PMID: 27462110
DOI: 10.1073/pnas.1605849113

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