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Article

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

Journal of autoimmunity - 1 Jun 2016

Messina Nicole, Fulford Thomas, O'Reilly Lorraine, Loh Wen Xian, Motyer Jessica M, Ellis Darcy, McLean Catriona, Naeem Haroon, Lin Ann, Gugasyan Raffi, Slattery Robyn M, Grumont Raelene J, Gerondakis Steve

Abstract excerpt

The properties of CD4(+) regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-κB transcription factor RelA is constitutively active in naïve and effector Tregs. The conditional inactivation of Rela in murine FOXP3(+) cells induces a rapid onset, multi-focal autoimmune disease that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27068879
DOI: 10.1016/j.jaut.2016.03.017

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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