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Article

The adaptive potential of circular DNA accumulation in ageing cells.

Current genetics - 1 Oct 2020

Hull Ryan M, Houseley Jonathan

Abstract excerpt

Carefully maintained and precisely inherited chromosomal DNA provides long-term genetic stability, but eukaryotic cells facing environmental challenges can benefit from the accumulation of less stable DNA species. Circular DNA molecules lacking centromeres segregate randomly or asymmetrically during cell division, following non-Mendelian inheritance patterns that result in high copy number instability and massive...

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Share to Adaptation, Physiological
Share to Cellular Senescence
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to DNA, Ribosomal

Share to Eukaryotic Cells

Share to Recombination, Genetic

Share to Saccharomyces cerevisiae

Source

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Identifiers

PMID: 32296868
DOI: 10.1007/s00294-020-01069-9
PMCID: PMC7497353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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